Decoding Cancer Through Epigenetics
Princess Margaret Cancer Centre • University Health Network • University of Toronto
Lab Website • GitHub • Contact
The Lupien Lab studies cancer as a disease of chromatin and epigenetic dysregulation.
We investigate how noncoding regulatory elements, 3D genome architecture, and chromatin accessibility drive cancer progression and therapeutic response.
Our team integrates:
- 🧬 Epigenomics (ATAC-seq, ChIP-seq, CUT&RUN, single-cell)
- 💻 Computational biology & machine learning
- 🔬 Functional genomics experiments
- 🧫 Cancer biology & translational research
To transform cancer care through epigenetics-driven discoveries and precision medicine.
- Clinical Relevance — target impactful cancer biology questions
- Functional Epigenomics — uncover regulatory drivers of cancer
- Precision Medicine — map chromatin features for therapeutic insights
- Accessible Methods — build robust, user-friendly wet & dry lab tools
- Clinical Translation — integrate epigenetics into patient care
The Lupien Lab develops open-source tools widely used in epigenomics research.
| Tool | Description |
|---|---|
| SMuRF | Identifies regulatory regions enriched in somatic mutations |
| MEMOS | Mutation Enrichment in Motifs |
| C3D | Predicts 3D interactions between cis-regulatory elements |
| RepeatEnrichment | Quantifies enrichment of repeat elements |
| Chromatin Accessibility Pipelines | End‑to‑end bulk ATAC-seq processing |
👉 Explore all projects: https://github.com/LupienLab
Clone any repository:
git clone https://github.com/LupienLab/<repo-name>.gitEach tool includes installation guides, pipelines, and usage examples.
We emphasize open science, reproducibility, and community-friendly tools. Feel free to reach out to us.
Lupien Lab
Princess Margaret Cancer Centre
MaRS Centre, PMCRT 11‑706
101 College Street, Toronto, ON, Canada
- Website: https://lupienlab.uhnresearch.ca/
- GitHub: https://github.com/LupienLab
Last updated: 2025‑12‑09